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Home»Articles»Microwave Assisted Rapid Extraction and Characterization of Coumarin from Fig Plant (Ficus carica)

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Asian Journal of Science and Applied Technology (AJSAT)

Editor Dr. Balaji Ramachandran
Print ISSN : 2249 - 0698
Frequency : Half-yearly

Microwave Assisted Rapid Extraction and Characterization of Coumarin from Fig Plant (Ficus carica)

Author : Resmi Mohan, M. Vidhyalakshmi and Venkatasubramanian Sivakumar
Volume 8 No.1 January-June 2019 pp 1-4

Abstract

Coumarins are fragrant natural bioactive organic compound find application as aroma, flavor and wide medicinal use. Fig plant (Ficus Carica) is a very good source of Coumarins. Coumarins are a member of the benzopyrone family and it has a benzene ring joined to a pyrone ring. There is a need for effective extraction and purification of Coumarins from plant materials. Different methods of extraction of Courmarin from Ficus Carica has been studied in this paper, among them, microwave extraction (180 W power) provided rapid extraction with 10 minutes time with extract yield of 0.67 g as compared to that of 1 hour of water bath extraction at 60C. Coumarin was isolated from the crude extract using NaOH and petroleum ether and their presence was characterized confirmed using UV spectroscopy, IR spectroscopy, TLC and fluorescence test. The antibacterial activity of coumarin was also evaluated using disc diffusion method and Minimum Inhibition Count (MIC). The present study analyzes and provides method of microwave assisted rapid extraction of Coumarin from Fig plant (Ficus Carica) and its characterization, which could be widely used as generic method from natural materials for different applications.

Keywords

Fig plant (Ficus Carica), Coumarin, Extraction Method, Microwave, Antibacterial

Full Text:

References

[1] K. Rohini, and P. S. Srikumar, “Therapeutic Role of Coumarins and Coumarin-Related Compounds”, Journal of Thermodynamics & Catalysis, Vol. 5, No. 2, pp.1-3, 2014.

[2] T. Ojala, “Biological Screening of Plant Coumarins”, PhD Thesis, University of Helsinki, Helsinki, Finland, 2001.

[3] D. Srikrishna, C. Godugu, and P. K. Dubey, “Review on Pharmacological Properties of Coumarins”, Mini Reviews in Medicinal Chemistry, Vol. 18, No. 2, pp. 113-141.2018.

[4] P. K.Jain and H.Joshi, “Coumarin: Chemical and Pharmacological Profile”, Journal of Applied Pharmaceutical Science, Vol.2, No.6, pp. 236-240, 2012.

[5] E. Nagaraju, C. Harika, K. Neelima Sandhya, S. Kumar, V. Reddy, K. Madhuri, and S. PhaniKasvr, “Phyto chemical screening and isolation of coumarin compounds from medicinal plant Vacha bark”. Journal of Atoms and Molecules, Vol. 2, pp. 149-154. 2012.

[6] R. D. H Murray, J. Mendez and S.A. Brown, “The Natural Coumarins –Occurrence, Chemistry and Biochemistry”, Chichester, John Wiley, 1982.

[7] K. Glowniak, “Investigation and isolation of coumarin derivatives from Polish plant material”, (in Polish.) Dissertation, Medical University, Lublin, 1988.

[8] L. Wu, X. Wang, W. Xu, F. Farzaneh, and R. Xu, “The Structure and Pharmacological Functions of Coumarins and their Derivatives”, Current Medicinal Chemistry, Vol. 16, pp. 4236-4260, 2009.

[9] D. Cooke, “Recent advances on coumarin and its synthetic derivatives”, Dublin City University, Dublin, Vol. 12, pp. 125-139, 1999.

[10] F. Conforti, G.Menichini, L. Zanfini, R. Tundis, G. A. Statti. E. Provenzano, F. Menichini, F. Sommaand and C. Alfano, “Evaluation of phototoxic potential of aerial components of the fig tree against human melanoma”, Cell Prolif., Vol. 45, pp. 279–285, 2012.

AJSAT is covering all aspects of Science and Applied Technology areas. Topics include, but are not limited to:

Chemistry
Physics
Astronomy
Earth Science
Environmental Science
Biology
Computer Science
Mathematics
Statistics
Systems Science

Coumarins are fragrant natural bioactive organic compound find application as aroma, flavor and wide medicinal use. Fig plant (Ficus Carica) is a very good source of Coumarins. Coumarins are a member of the benzopyrone family and it has a benzene ring joined to a pyrone ring. There is a need for effective extraction and purification of Coumarins from plant materials. Different methods of extraction of Courmarin from Ficus Carica has been studied in this paper, among them, microwave extraction (180 W power) provided rapid extraction with 10 minutes time with extract yield of 0.67 g as compared to that of 1 hour of water bath extraction at 60C. Coumarin was isolated from the crude extract using NaOH and petroleum ether and their presence was characterized confirmed using UV spectroscopy, IR spectroscopy, TLC and fluorescence test. The antibacterial activity of coumarin was also evaluated using disc diffusion method and Minimum Inhibition Count (MIC). The present study analyzes and provides method of microwave assisted rapid extraction of Coumarin from Fig plant (Ficus Carica) and its characterization, which could be widely used as generic method from natural materials for different applications.

Editor-in-Chief
Dr. Balaji Ramachandran
Department of Applied Sciences, Nicholls State University, Louisiana, United States
[email protected]
Editorial Advisory Board
Dr. Maamar Benkraouda
Department of Physics, United Arab Emirates University, UAE
[email protected]
Dr. Rasheed Al Hammadi
Department of Biology, United Arab Emirates University, UAE
[email protected]
Dr. Dimitrios P. Nikolelis
Department of Chemistry, University of Athens, Greece
[email protected]
Dr. Fauziah Binti Shahul Hamid
Institute of Biological Sciences, University of Malaya, Malaysia
[email protected]
Dr. Karni S Moshal
Department of Medicine, Alpert Medical School of Brown University, USA
[email protected]
Dr. Koh You Beng
Institute of Mathematical Sciences, University of Malaya, Malaysia
[email protected]
Dr. Lim Sok Li
Institute of Mathematical Sciences, University of Malaya, Malaysia
[email protected]
Dr. Ramesh Kasi
Department of Physics, University of Malaya, Malaysia
[email protected]
Dr. Jasmine Elanie Binti Khairat
Institute of Biological Sciences, University of Malaya, Malaysia
[email protected]
Dr. Nur Airina Binti Muhamad
Institute of Biological Sciences, University of Malaya, Malaysia
[email protected]
Dr. Amizah Malip
Department of Applied Mathematics, University of Malaya, Malaysia
[email protected]
Dr. Azzuliani Binti Supangat
Department of Physics, University of Malaya, Malaysia
[email protected]
Prof. Mohamed Toutounji
Professor, Department of Chemistry, United Arab Emirates University, UAE
[email protected]
Dr. Mohd Azmi Haron
Institute of Mathematical Sciences, University of Malaya, Malaysia
[email protected]
Prof. Noordini Mohamad Salleh
Department of Chemistry, University of Malaya, Malaysia
[email protected]
Dr. Ibrahim Bin Mohamed
Institute of Mathematical Sciences, University of Malaya, Malaysia
[email protected]
Dr. Halijah Ibrahim
Institute of Biological Sciences, University of Malaya, Malaysia
[email protected]
Dr. S. Chandra Kishore
Assistant Professor, University of Information Science and Technology,
“St. Paul The Apostle”, Macedonia, Greece
[email protected]
Dr. Salah Nasri
Department of Physics, United Arab Emirates University, UAE
[email protected]
Dr. Dharini Pathmanathan
Institute of Mathematical Sciences, University of Malaya, Malaysia
[email protected]

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    Editorial Note

    Editorial Dr. Balaji Ramachandran

    Editor-in-Chief
    Dr. Balaji Ramachandran
    Department of Applied Sciences, Nicholls State University, Louisiana, United States
    [email protected]
    Editorial Advisory Board
    Dr. Maamar Benkraouda
    Department of Physics, United Arab Emirates University, UAE
    [email protected]
    Dr. Rasheed Al Hammadi
    Department of Biology, United Arab Emirates University, UAE
    [email protected]
    Dr. Dimitrios P. Nikolelis
    Department of Chemistry, University of Athens, Greece
    [email protected]
    Dr. Fauziah Binti Shahul Hamid
    Institute of Biological Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. Karni S Moshal
    Department of Medicine, Alpert Medical School of Brown University, USA
    [email protected]
    Dr. Koh You Beng
    Institute of Mathematical Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. Lim Sok Li
    Institute of Mathematical Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. Ramesh Kasi
    Department of Physics, University of Malaya, Malaysia
    [email protected]
    Dr. Jasmine Elanie Binti Khairat
    Institute of Biological Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. Nur Airina Binti Muhamad
    Institute of Biological Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. Amizah Malip
    Department of Applied Mathematics, University of Malaya, Malaysia
    [email protected]
    Dr. Azzuliani Binti Supangat
    Department of Physics, University of Malaya, Malaysia
    [email protected]
    Prof. Mohamed Toutounji
    Professor, Department of Chemistry, United Arab Emirates University, UAE
    [email protected]
    Dr. Mohd Azmi Haron
    Institute of Mathematical Sciences, University of Malaya, Malaysia
    [email protected]
    Prof. Noordini Mohamad Salleh
    Department of Chemistry, University of Malaya, Malaysia
    [email protected]
    Dr. Ibrahim Bin Mohamed
    Institute of Mathematical Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. Halijah Ibrahim
    Institute of Biological Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. S. Chandra Kishore
    Assistant Professor, University of Information Science and Technology,
    “St. Paul The Apostle”, Macedonia, Greece
    [email protected]
    Dr. Salah Nasri
    Department of Physics, United Arab Emirates University, UAE
    [email protected]
    Dr. Dharini Pathmanathan
    Institute of Mathematical Sciences, University of Malaya, Malaysia
    [email protected]

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