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Home»Articles»Negligible Protection of Pancreas by Topical Curcumin in Streptozotocin Induced Diabetic Wounded Rats

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Asian Journal of Science and Applied Technology (AJSAT)

Editor Dr. Balaji Ramachandran
Print ISSN : 2249 - 0698
Frequency : Half-yearly

Negligible Protection of Pancreas by Topical Curcumin in Streptozotocin Induced Diabetic Wounded Rats

Author : Vinay Kant, Dinesh Kumar1, Vijayta Gupta, and Babu L Jangir
Volume 9 No.1 January-June 2020 pp 10-13

Abstract

Damage or non-functioning of beta cells of Langerhans is lets of pancreas causes Type I diabetes. Curcumin, a bioflavonoid, have shown some tissue regenerative properties. It has shown a very good wound healing actions in diabetic animals after topical applications. In view of this, we planned to study the regenerative action of curcumin on damaged pancreas of diabetic rats after its topical applications on wounds. Damage of pancreas and induction of Type I diabetes in rats was achieved by single intraperitoneal injection of streptozotocin (60mg/kg b.wt.). Thereafter, open excisional wounds were created and wounded rats were divided into three groups viz. i) healthy control (non-diabetic), ii) Diabetic control and iii) Diabetic-treated. Pluronic F-127 gel (25%) was applied topically on wounds of group I and II once daily for 19 days. Curcumin (0.3%) in gel was topically applied similarly on group III. Average body weight gain was less and blood glucose levels were high in group II and III. There were also higher levels of MDA in group II and III. Histopathologically, atrophy and loss of intactness of beta cells of langerhans is lets in the pancreas were evident in group II and III, as compared to group I. In conclusion, topical applications of curcumin on wounds of diabetic rats did not able to prevent the damage of beta cells of the pancreas produced by single intraperitoneal injection of streptozotocin (60mg/kg b.wt.). In future, the other higher or lower concentrations of curcumin and their nano-formulations may be tried to evaluate the protective actions.

Keywords

Streptozotocin, Pancreas, Curcumin, Wound

Full Text:

References

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AJSAT is covering all aspects of Science and Applied Technology areas. Topics include, but are not limited to:

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Damage or non-functioning of beta cells of Langerhans is lets of pancreas causes Type I diabetes. Curcumin, a bioflavonoid, have shown some tissue regenerative properties. It has shown a very good wound healing actions in diabetic animals after topical applications. In view of this, we planned to study the regenerative action of curcumin on damaged pancreas of diabetic rats after its topical applications on wounds. Damage of pancreas and induction of Type I diabetes in rats was achieved by single intraperitoneal injection of streptozotocin (60mg/kg b.wt.). Thereafter, open excisional wounds were created and wounded rats were divided into three groups viz. i) healthy control (non-diabetic), ii) Diabetic control and iii) Diabetic-treated. Pluronic F-127 gel (25%) was applied topically on wounds of group I and II once daily for 19 days. Curcumin (0.3%) in gel was topically applied similarly on group III. Average body weight gain was less and blood glucose levels were high in group II and III. There were also higher levels of MDA in group II and III. Histopathologically, atrophy and loss of intactness of beta cells of langerhans is lets in the pancreas were evident in group II and III, as compared to group I. In conclusion, topical applications of curcumin on wounds of diabetic rats did not able to prevent the damage of beta cells of the pancreas produced by single intraperitoneal injection of streptozotocin (60mg/kg b.wt.). In future, the other higher or lower concentrations of curcumin and their nano-formulations may be tried to evaluate the protective actions.

Editor-in-Chief
Dr. Balaji Ramachandran
Department of Applied Sciences, Nicholls State University, Louisiana, United States
[email protected]
Editorial Advisory Board
Dr. Maamar Benkraouda
Department of Physics, United Arab Emirates University, UAE
[email protected]
Dr. Rasheed Al Hammadi
Department of Biology, United Arab Emirates University, UAE
[email protected]
Dr. Dimitrios P. Nikolelis
Department of Chemistry, University of Athens, Greece
[email protected]
Dr. Fauziah Binti Shahul Hamid
Institute of Biological Sciences, University of Malaya, Malaysia
[email protected]
Dr. Karni S Moshal
Department of Medicine, Alpert Medical School of Brown University, USA
[email protected]
Dr. Koh You Beng
Institute of Mathematical Sciences, University of Malaya, Malaysia
[email protected]
Dr. Lim Sok Li
Institute of Mathematical Sciences, University of Malaya, Malaysia
[email protected]
Dr. Ramesh Kasi
Department of Physics, University of Malaya, Malaysia
[email protected]
Dr. Jasmine Elanie Binti Khairat
Institute of Biological Sciences, University of Malaya, Malaysia
[email protected]
Dr. Nur Airina Binti Muhamad
Institute of Biological Sciences, University of Malaya, Malaysia
[email protected]
Dr. Amizah Malip
Department of Applied Mathematics, University of Malaya, Malaysia
[email protected]
Dr. Azzuliani Binti Supangat
Department of Physics, University of Malaya, Malaysia
[email protected]
Prof. Mohamed Toutounji
Professor, Department of Chemistry, United Arab Emirates University, UAE
[email protected]
Dr. Mohd Azmi Haron
Institute of Mathematical Sciences, University of Malaya, Malaysia
[email protected]
Prof. Noordini Mohamad Salleh
Department of Chemistry, University of Malaya, Malaysia
[email protected]
Dr. Ibrahim Bin Mohamed
Institute of Mathematical Sciences, University of Malaya, Malaysia
[email protected]
Dr. Halijah Ibrahim
Institute of Biological Sciences, University of Malaya, Malaysia
[email protected]
Dr. S. Chandra Kishore
Assistant Professor, University of Information Science and Technology,
“St. Paul The Apostle”, Macedonia, Greece
[email protected]
Dr. Salah Nasri
Department of Physics, United Arab Emirates University, UAE
[email protected]
Dr. Dharini Pathmanathan
Institute of Mathematical Sciences, University of Malaya, Malaysia
[email protected]

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    Editorial Note

    Editorial Dr. Balaji Ramachandran

    Editor-in-Chief
    Dr. Balaji Ramachandran
    Department of Applied Sciences, Nicholls State University, Louisiana, United States
    [email protected]
    Editorial Advisory Board
    Dr. Maamar Benkraouda
    Department of Physics, United Arab Emirates University, UAE
    [email protected]
    Dr. Rasheed Al Hammadi
    Department of Biology, United Arab Emirates University, UAE
    [email protected]
    Dr. Dimitrios P. Nikolelis
    Department of Chemistry, University of Athens, Greece
    [email protected]
    Dr. Fauziah Binti Shahul Hamid
    Institute of Biological Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. Karni S Moshal
    Department of Medicine, Alpert Medical School of Brown University, USA
    [email protected]
    Dr. Koh You Beng
    Institute of Mathematical Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. Lim Sok Li
    Institute of Mathematical Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. Ramesh Kasi
    Department of Physics, University of Malaya, Malaysia
    [email protected]
    Dr. Jasmine Elanie Binti Khairat
    Institute of Biological Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. Nur Airina Binti Muhamad
    Institute of Biological Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. Amizah Malip
    Department of Applied Mathematics, University of Malaya, Malaysia
    [email protected]
    Dr. Azzuliani Binti Supangat
    Department of Physics, University of Malaya, Malaysia
    [email protected]
    Prof. Mohamed Toutounji
    Professor, Department of Chemistry, United Arab Emirates University, UAE
    [email protected]
    Dr. Mohd Azmi Haron
    Institute of Mathematical Sciences, University of Malaya, Malaysia
    [email protected]
    Prof. Noordini Mohamad Salleh
    Department of Chemistry, University of Malaya, Malaysia
    [email protected]
    Dr. Ibrahim Bin Mohamed
    Institute of Mathematical Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. Halijah Ibrahim
    Institute of Biological Sciences, University of Malaya, Malaysia
    [email protected]
    Dr. S. Chandra Kishore
    Assistant Professor, University of Information Science and Technology,
    “St. Paul The Apostle”, Macedonia, Greece
    [email protected]
    Dr. Salah Nasri
    Department of Physics, United Arab Emirates University, UAE
    [email protected]
    Dr. Dharini Pathmanathan
    Institute of Mathematical Sciences, University of Malaya, Malaysia
    [email protected]

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