Photocatalytic Degradation of Allopurinol using Cerium Oxide
Author : K. Sridevi Lakshmi , J. Jeyanthi and R. BhuvaneswariVolume 7 No.2 July-December 2018 pp 39-44
Abstract
Allopurinol (AP) is an antigout drug under the brand names Zyloprim and Zyloric. It is a structural isomer of hypoxanthine, a naturally occurring purine in the body which inhibits xanthine oxidase that results in decrease in uric acid formation. In this work, degradation of aqueous solution of Allopurinol by photocatalysis was studied using CeO2. The CeO2 was synthesized by Co-Precipitation method and it was characterized by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM/EDAX), FTIR and BET Surface Area Analyzer. FTIR confirms the finger print region for CeO2around 829.92cm-1. Surface area of CeO2 was measured as 64.42m2g-1 by BET surface area analysis. The optical and thermal stability was determined using DRS UV-Visible spectroscopy and Thermo gravimetric analysis. In this study the concentrations of Allopurinol was quantified using UV-Visible Spectroscopy. The feasibility of photo degradation of allopurinol using CeO2 was carried out in the presence of UV irradiation of 254 nm. The optimization of process control parameters such as catalyst dosage, pH and allopurinol concentration was assessed. From the assessment, degradation rate decreases with increase in initial concentration of Allopurinol whereas it increases with increase in CeO2 concentration up to 0.04g/l. In case of pH, degradation constant increases with increase in pH from 8.5 to 11.
Keywords
Allopurinol, Cerium oxide, Characterization, Photocatalysis
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