Asian Journal of Science and Applied Technology (AJSAT)
Promising Health Benefits of Hippophae rhamnoides L. (Sea Buckthorn): A Miracle Plant
Author : Madhuri Mehta, Vijayta Gupta, Vinay Kant and Chandresh VarshneyaVolume 8 No.1 January-June 2019 pp 10-15
Abstract
Seabuckthorn (Hippophae rhamnoides L.), a spiny bush plant native to Europe and Asia, have many nutritional and medicinal properties. All parts of this plant are rich source of bioactive components such as, tocopherols, carotenoids, flavonoids, vitamins, sugar, organic acids and minerals. Various in vivo and in vitro studies on animals and human suggest that seabuckthorn has many beneficial effects as cardioprotective, antiatherogenic, antioxidant, anticancer, immunomodulatory, anti-bacterial, antiviral and anti-inflammatory, which reveals its medicinal and pharmacological properties. Seabuckthorn can be supplemented as nutraceuticals in animal feed to enhance its antioxidative potential, strengthen the immune system, which may help the organism to resist stress. To promote the large scale utilization of seabuckthorn, it would be worthwhile to perform more research on this plant.
Keywords
Seabuckthorn, Anti-Cancer, Antioxidant, Anti-Inflammatory
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References
[1] I. I. Brekhman, Man and Biologically Active Substances. 1st ed., Oxford, England: Pergamon Press, 1980.
[2] S. Fulder, “The drug that builds Russians”, New Scientist, Vol. 88, pp. 576-579, 1980.
[3] P. Scartezzini, and E. Speroni, “Review on some plants of Indian traditional medicine with antioxidant activity”, Journal of Ethanopharmacology, Vol. 71, pp. 23-43, 2000.
[4] A. Rousi, “The genus Hippophae L., a taxonomic study”, Annals Botanica Fennici, Vol. 8, pp. 177-227, 1971.
[5] D. Dhyani, R. K. Maikhuri, S. Misra, and K. S. Rao, “Endorsing the declining indigenous ethnobotanical knowledge system of Seabuckthorn in Central Himalaya, India”, Journal of Ethanopharmacology, Vol. 127, pp. 329-34, 2010.
[6] T. Xiaoping, S. Qaiohong, C. Xiaolon, and C. Jun, Study of biochemical pharmacology of Seabuckthorn fruit oil and its compound health products, In: Proceedings of International workshop on Seabuckthorn. Beijing, 1995, pp. 162-164.
[7] V. K. Yadav, V. K. Sah, A. K. Singh, and S. K. Sharma, “Variations in morphological and biochemical characters of Seabuckthorn (Hippophae salicifolia D. Don.) populations growing in Harsil area of Garhwal Himalaya in India”, Tropical Agricultural Research and Extension, Vol. 9, pp. 1-7, 2006.
[8] R. Lu, Sea buckthorn: A multipurpose plant species for fragile mountains, International Centre for Integrated Mountain Development, Karmandu, Nepal, 1992.
[9] V. Singh, Seabuckthorn (Hippophae L.) in traditional medicines, In: Seabuckthorn (Hippophae L.): A Multipurpose Wonder Plant. New Delhi, India: Daya Publishing House, 2005. Vol. 2, pp. 505-521.
[10] L. H. Shi, H. J. Cai, X. Y. Chen, and C. M. Yang, “Study on the Antioxidation effect of Hippophae rhamnoides L. seed oil”, Acta Nutrimenta Sinica, Vol. 3, pp. 292-295, 1994.
[11] Y. B. Ji, and Y. Gao, “Effect of feeding sea buckthorn seed oil and sea buckthorn seed oil supplemented with sodium selenite in vivo on structural stability of erythrocyte ghosts in rats”, Journal of Biological Chemistry, Vol. 7, pp. 441-446, 1991.
[12] B. Yang, K. O. Kalimo, L. M. Mattila, S. E. Kallio, J. K. Katajisto, O. J. Peltola, and H. P. Kallio, “Effects of dietary supplementation with sea buckthorn (Hippophae rhamnoides L.) seed and pulp oils on atopic dermatitis”, Journal of Nutritional Biochemistry, Vol.10, pp. 622-630, 1999.
[13] J. Xing, B. Yang, Y. Dong, B. Wang, J. Wang, and P. H. Kallio, “Effects of sea buckthorn (Hippophae rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats”, Fitoterapia, Vol. 73, pp. 644-650, 2002.
[14] M. Spansu, R. Morar, E. Morar, P. Brudasca, M. Oprea, and S. Tordai, “Effect of different treatment schedules with “Polivitarom” (Hippophae rhamnoides extracts) and humoral and cellular immune response in rabbits”, MedivinoVeterinaria, Vol. 48, pp. 281-288, 1994.
[15] S. Geetha, M. S. Ram, V. Singh, G. Ilavazhagan, and R. C. Sawhney, “Evaluation of antioxidant activity of leaf extract of Sea buckthorn (Hippophae rhamnoides L.) on chromium (VI) induced oxidative stress in male albino rats”, Journal of Ethnopharmacology, Vol. 87, pp. 247-251, 2003.
[16] W. Zhang, J. Yan, J. Duo, B. Ren, and J. Guo, Preliminary study of biochemical constitutions of berry of sea buckthorn growing in Shanxi province and their changing trend, In: Proceedings of international symposium on sea buckthorn (H. rhamnoides L.), Xian, China: 1989, pp. 96−105.
[17] T. Cheng, T. Li, Z. Duan, Z. Cao, Z. Ma, and P. Zhang, “Acute toxicity of flesh oil of Hippophaerhamnoides L. and its protection against experimental hepatic injury” Zhongguo Zhong Yao Za Zhi, Vol. 15, pp. 45-47, 1990.
[18] X. Yaonian, L. Yonghai, W. Sulin, S. Xiuzhi, and K. Aiztmuller, A study of the compositions of seabuckthorn oils in China, In: Proceedings of International Workshop on Seabuckthorn. Beijing: 1995.
[19] A. Zeb, “Important therapeutic uses of Sea buckthorn (Hippophae): a review”, Journal of Biological Sciences, Vol. 4, pp. 687-693, 2004.
[20] H. M. Leskinen, J. P. Suomela, B. Yang, and H. P. Kallio, “Regioisomer compositions of vaccenic and oleic acid containing triacylglycerols in sea buckthorn (Hippophae rhamnoides) pulp oils: influence of origin and weather conditions”, Journal of Agricultural and Food Chemistry, Vol. 58, pp. 537-545, 2010.
[21] B. R. Yang, “Lipophilic components of sea buckthorn (Hippophaėrhamnoides) seeds and berries and physiological effects of sea buckthorn oils”, PhD thesis, Turku University, Finland, 2001.
[22] H. Kallio, B. Yang, and P. Peippo, “Effects of different origins and harvesting time on vitamin C, tocopherols and tocotrienols in Sea buckthorn (Hippophae rhamnoides L.) berries”, Journal of Agricultural and Food Chemistry, Vol. 50, pp. 6136-6142, 2002.
[23] S. C. Andersson, M. E. Olsson, E. Johansson, and K. Rumpunen, “Carotenoids in sea buckthorn (Hippophae rhamnoides L.) berries during ripening and use of pheophytin a as a maturity marker”, Journal of Agricultural and Food Chemistry, Vol. 57, pp. 250-258, 2009.
[24] B, Yang, and H. P. Kallio, “Fatty acid composition of lipids in Sea buckthorn (Hippophae rhamnoides L.) berries of different origins”, Journal of Agricultural and Food Chemistry, Vol. 49, pp. 1939-1947, 2001.
[25] R. K. Gupta, and V. Singh, Mineral composition of Seabuckthorn (Hippophae L.), In: Seabuckthorn (Hippophae L.): A Multipurpose Wonder Plant. New Delhi, India: Daya Publishing House, 2005. Vol. 2, pp. 272-284.
[26] A. S. Chauhan, M. N. Rekha, R. S. Ramteke, and W. E. Eipeson, “Preparation and quality evaluation of processed products from sea buckthorn (Hippophaė rhamnoides Lin.) berries”, Beverage and Food World, Vol. 1, pp. 31−34, 2001.
[27] S. Geetha, M. S. Ram, V. Singh, G. Ilavazhagan, and R. C. Sawhney, “Antioxidant and immunomodulatory properties of Sea buckthorn (Hippophae rhamnoides) – an in vitro study”, Journal of Ethnopharmacology, Vol. 79, pp. 373-378, 2002a.
[28] S. Geetha, M. S. Ram, V. Singh, G. Ilavazhagan, and R. C. Sawhney, “Immunomodulatory effects of seabuckthorn (Hippophae rhamnoides L.) against chromium (VI) induced immunosuppression”, Molecular and Cellular Biochemistry, Vol. 278, pp. 101-109, 2005.
[29] K. P. Mishra, R. Mishra, A. P. Yadav, B. Jayashankar, S. Chanda, and L. Ganju, “A comparative analysis of immunomodulatory potential of Seabuckthorn leaf extract in young and old mice”, Biomedicine and Aging Pathology, Vol. 1, pp. 61-64, 2011.
[30] T. Ramasamy, C. Varshneya, and V. C. Katoch, “Immunoprotective effect of Seabuckthorn (Hippophae rhamnoides) and Glucomannan on T-2 toxin-induced immunodepression in poultry”, Veterinary Medicine International, 6 pages, 2010, DOI: 10.4061/2010/149373.
[31] S. Narayanan, D. Ruma, B. Gitika, S. K. Sharma, T. Pauline, M. S. Ram, G. Ilavazhagan, R.C. Sawhney, D. Kumar, and P.K. Banerjee, “Antioxidant activities of seabuckthorn (Hippophae rhamnoides) during hypoxia induced oxidative stress in glial cells”, Molecular and Cellular Biochemistry, Vol. 278, pp. 9-14, 2005.
[32] C. Varshneya, V. Kant, and M. Mehta, “Total phenolic contents and free radical scavenging activities of different extracts of seabuckthorn (Hippophae rhamnoides) pomace without seeds”, International Journal of Food Sciences and Nutrition, Vol, 63, pp. 153-159, 2012.
[33] V. Kant, M. Mehta, and C. Varshneya, “Antioxidant potential and total phenolic contents of Seabuckthorn(Hippophae rhamnoides) pomace”, Free Radical and Antioxidants, Vol. 2, pp. 79-86, 2012.
[34] M. Mehta, V. Kant, and C. Varshneya, “Screening of in vitro antioxidant potential of seabuckthorn seedcake extracts”, Journal of Intercultural Ethnopharmacology, Vol. 2, pp. 99-104, 2013.
[35] X. Pang, J. Zhao, W. Zhang, X. Zhuang, J. Wang, R. Xu, Z. Xu, and W. Qu, “Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats”, Journal of Ethnopharmacology, Vol. 117, pp. 325-331, 2008.
[36] J. Cheng, K. Kondoa, Y. Suzuki, Y. Ikeda, X. Meng, and K. Umemura, “Inhibitory effects of total flavones of Hippophae rhamnoides on thrombosis in mouse femoral artery and in vitro platelet aggregation”, Life Science, Vol. 72, pp. 2263-2271, 2003.
[37] M, Bao, and Y. Lou, “Flavonoids from seabuckthorn protect endothelial cells (EA.hy926) from oxidized low-density lipoprotein induced injuries via regulation of LOX-1 and eNOS expression”, Journal of Cardiovascular Pharmacology, Vol. 48, pp. 834-841, 2006.
[38] M. Basu, R. Prasad, P. Jayamurthy, K. Pal, C. Arumughan, and R. C. Sawhney, “Anti-atherogenic effects of Sea buckthorn (Hippophae rhamnoides) seed oil”, Phytomedicine, Vol. 14, pp. 770-777, 2007.
[39] D. T. Maheshwari, M. S. Y. Kumar, S. K. Verma, V. K. Singh, and S. N. Singh, “Antioxidant and hepatoprotective activities of phenolic rich fraction of Seabuckthorn (Hippophae rhamnoides L.) leaves”, Food and Chemical Toxicology, Vol. 49, pp. 2422-2428, 2011.
[40] S. Geetha, P. Jayamurthy, K. Pal, S. Pandey, and R. C. Sawhney, “Hepatoprotective activity of Sea buckthorn (Hippophae rhamnoides L.) against carbon tetrachloride induced hepatic damage in rats”, Journal of the Science of Food and Agriculture, Vol. 88, pp. 1592-1597, 2008.
[41] Y. Hsu, C. Tsai, W. Chen, and L. Fung-Jou, “Protective effects of Seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice”, Food and Chemical Toxicology, Vol. 47, pp. 2281-2288, 2009.
[42] K. Yasukawa, S. Kitanaka, K. Kawata, and K. Goto, “Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides”, Fitoterepia, Vol. 80, pp. 164-167, 2009.
[43] C. Grey, C. Widen, P. Adlercreutz, K. Rumpunen, and R. D. Duan, “Antiproliferative effects of sea buckthorn (Hippophae rhamnoides L.) extracts on human colon and liver cancer cell lines”, Food Chemistry, Vol, 120, pp.1004-1010, 2010.
[44] B. Padmavathi, M. Upreti, V. Singh, A. R. Rao, R. P. Singh, and P. C. Rath, “Chemoprevention by Hippophae rhamnoides: effects on tumorigenesis, phase II and antioxidant enzymes, and IRF-1 transcription factor”, Nutrition and Cancer, Vol. 51, pp. 59-67, 2005.
[45] B. S. Teng, Y. H. Lu, Z. T. Wang, X. Y. Tao, and D. Z. Wei, “In vitro anti-tumor activity of isorhamnetin isolated from Hippophae rhamnoides L. against BEL-7402 cells”, Pharmacological Research, Vol. 54, pp. 186-194, 2006.
[46] T. S. C. Li, and W. R. Schroeder, “Sea buckthorn (Hippophae rhamnoides L.): a multipurpose plant”, Horticulture Technology, Vol. 6, pp. 370-380, 1996.
[47] T. Beveridge, T. S. C. Li, B. D. Oomah, and A. Smith, “Sea buckthorn products: manufacture and composition”, Journal of Agricultural and Food Chemistry, Vol. 47, pp. 3480-3488, 1999.
[48] A. Gupta, R. Kumar, K. Pal, P. K. Banerjee, and R. C. Sawhney, “A preclinical study of the effects of Sea buckthorn (Hippophae rhamnoides L.) leaf extract on cutaneous wound healing in albino rats”, International Journal of Lower Extremity Wounds, Vol, 4, pp. 88-92, 2005.
[49] A. Gupta, R. Kumar, K. Pal, P. K. Banerjee, and R. C. Sawhney, “Influence of Sea buckthorn (Hippophae rhamnoides L.) flavone on dermal wound healing in rats”, Molecular and Cellular Biochemistry, Vol. 290, pp. 193-198, 2006.
[50] A. Gupta, N. K. Upadhyay, R. C. Sawhney, and R. Kumar, “A poly-herbal formulation accelerates normal and impaired diabetic wound healing”, Wound Repair and Regeneration, Vol. 16, pp. 784-790, 2008.
[51] N. K. Upadhyay, R. Kumar, S. K. Mandotra, R. N. Meena, M. S. Siddiqui, R. C. Sawhney, and A. Gupta, “Safety and wound healing efficacy of sea buckthorn (Hippophae rhamnoides L.) seed oil in experimental rats”, Food and Chemical Toxicology, Vol. 47, pp. 1146-1153, 2009.
[52] W. L. Zhang, Z. F. Zhang, J. J. Fan, S. Y. Yang, Z. M. Li, and Z. C. Deng, “Experimental observation and clinical investigation effect of sea buckthorn oil on acute radio dermatitis”, Hippophae, Vol. 1, pp. 27-30, 1988.
[53] B. Yang, K. O. Kalimo, R. L. Tahvonen, L. M. Mattila, J. K. Katajisto, and H. P. Kallio, “Effect of dietary supplementation with sea buckthorn (Hippophae rhamnoides) seed and pulp oils on the fatty acid composition of skin glycerophospholipids of patients with atopic dermatitis”, Journal of Nutritional Biochemistry, Vol. 11, pp. 338-340, 2000.
[54] N. K. Upadhyay, R. Kumar, M. S. Siddiqui, and A. Gupta, “Mechanism of wound healing activity of Hippophae rhamnoides L. leaf extract in experimental burns”, Evidence Based Complementary and Alternative Medicine, 2011, DOI: 10.1093/ecam/nep189.
[55] S. Geetha, and A. Gupta, “Medicinal and therapeutic potential of Sea buckthorn (Hippophae rhamnoides L.)”, Journal of Ethnopharmacology, Vol. 138, pp. 268-278, 2011.
[56] L. D. Shipulina, O. N. Tolkachev, L. V. Krepkova, V. V. Bortnikova, and A. A. Shkarenkov, Anti-viral anti-microbial and toxicological studies on Seabuckthorn (Hippophae rhamnoides), In: Seabuckthorn (Hippophae L.): A Multipurpose Wonder Plant. New Delhi, India: Daya Publishing House, 2005. Vol. 2, pp. 471-483.
[57] M. Jain, L. Ganju, A. Katiyal, Y. Padwad, K. P. Mishra, S. Chanda, D. Karan, K. M. Yogendra, and R. C. Sawhney, “Effect of Hippophae rhamnoides leaf extract against Dengue virus infection in human blood-derived macrophages”, Phytomedicine, Vol. 15, pp. 793-799, 2008.
[58] A. S. Chauhan, P. S. Negi, and R. S. Ramteke, “Antioxidant and antibacterial activities of aqueous extract of Sea buckthorn (Hippophae rhamnoides) seeds”, Fitoterapia, Vol. 78, pp. 590-592, 2007.
[59] N. K. Upadhyay, M. S. Y. Kumar, and A. Gupta, “Antioxidant, cytoprotective and antibacterial effects of Sea buckthorn (Hippophae rhamnoides L.) leaves”, Food and Chemical Toxicology, Vol. 48, pp. 3443-3448, 2010.
[60] B. A. Fayman, “Treatment of operative wounds in ear, nose, throat with Seabuckthorn oil”, Seabuckthorn, Vol. 4, pp. 7, 1991.
[61] L.V. Sabynich, L.A. Sibileva, L.S. Belova, and V.S. Chuchalin, “Anti inflammatory of thick extract from fruit of pulp of Hippophae rhamnoids L.”, Rastitelnye Resursy, Vol. 30, pp. 70-74, 1994.
[62] Z. L. Gao, X. H. Zu, F. T. Cheng, and F. H. Jiang, “Effect of Seabuckthorn on liver fibrosis: a clinical study”, World Journal of Gastroenterology, Vol. 9, pp. 1615-1617, 2003.